Invention Grant
- Patent Title: Macrocyclics pyrimidines as aurora kinase inhibitors
- Patent Title (中): 大环嘧啶作为极光激酶抑制剂
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Application No.: US13062413Application Date: 2009-09-03
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Publication No.: US08815872B2Publication Date: 2014-08-26
- Inventor: Henry Yu , Lizbeth Celeste De Selm , Xuliang Jiang , Benny C. Askew, Jr. , Srinivasa R. Karra , Andreas Goutopoulos
- Applicant: Henry Yu , Lizbeth Celeste De Selm , Xuliang Jiang , Benny C. Askew, Jr. , Srinivasa R. Karra , Andreas Goutopoulos
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: EMD Serono Research Institute
- Agent Thomas W. Brown
- International Application: PCT/US2009/055841 WO 20090903
- International Announcement: WO2010/028116 WO 20100311
- Main IPC: A61K31/529
- IPC: A61K31/529 ; C07D239/42 ; C07D487/08 ; C07D487/18 ; C07D498/08 ; C07D498/18 ; C07D513/08 ; C07D513/18 ; C07D515/08
Abstract:
Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.
Public/Granted literature
- US20110294801A1 MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS Public/Granted day:2011-12-01
Information query
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