Invention Grant
US08815895B2 Mediators of hedgehog signaling pathways, compositions and uses related hereto
有权
刺猬信号通路的调解者，组合物和用途相关
- Patent Title: Mediators of hedgehog signaling pathways, compositions and uses related hereto
- Patent Title (中): 刺猬信号通路的调解者，组合物和用途相关
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Application No.: US13421899Application Date: 2012-03-16
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Publication No.: US08815895B2Publication Date: 2014-08-26
- Inventor: Oivin M. Guicherit , Edward Andrew Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. Mackinnon
- Applicant: Oivin M. Guicherit , Edward Andrew Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. Mackinnon
- Applicant Address: US MA Lexington US CA South San Francisco
- Assignee: Curis, Inc.,Genentech, Inc.
- Current Assignee: Curis, Inc.,Genentech, Inc.
- Current Assignee Address: US MA Lexington US CA South San Francisco
- Agency: Millen, White, Zelano & Branigan, P.C.
- Main IPC: A61K31/4427
- IPC: A61K31/4427
Abstract:
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
Public/Granted literature
- US20120283258A1 MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO Public/Granted day:2012-11-08
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