Invention Grant
US08815902B2 Tetrahydroquinoline amide M1 receptor positive allosteric modulators
有权
四氢喹啉酰胺M1受体阳性变构调节剂
- Patent Title: Tetrahydroquinoline amide M1 receptor positive allosteric modulators
- Patent Title (中): 四氢喹啉酰胺M1受体阳性变构调节剂
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Application No.: US13704259Application Date: 2011-06-10
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Publication No.: US08815902B2Publication Date: 2014-08-26
- Inventor: Kevin F. Gilbert , Scott D. Kuduk
- Applicant: Kevin F. Gilbert , Scott D. Kuduk
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- International Application: PCT/US2011/039894 WO 20110610
- International Announcement: WO2011/159554 WO 20111222
- Main IPC: C07D215/48
- IPC: C07D215/48 ; A61K31/4709
Abstract:
The present invention is directed to tetrahydroquinoline amide compounds of formula (I) (Formula should be inserted here) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20130090352A1 TETRAHYDROQUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2013-04-11
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