Invention Grant
- Patent Title: Bivalent diazo bicyclic Smac mimetics and the uses thereof
- Patent Title (中): 二价重氮二环Smac模拟物及其用途
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Application No.: US13503366Application Date: 2010-10-20
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Publication No.: US08815927B2Publication Date: 2014-08-26
- Inventor: Shaomeng Wang , Haiying Sun
- Applicant: Shaomeng Wang , Haiying Sun
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- International Application: PCT/US2010/053384 WO 20101020
- International Announcement: WO2011/050068 WO 20110428
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D403/14 ; C07D245/04 ; C07D519/00
Abstract:
The invention relates to diazo bicyclic Smac mimetics that are tethered through a covalent linker to give a bivalent species. Bivalent diazo bicyclic Smac mimetics function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs). The invention also relates to the use of bivalent diazo bicyclic Smac mimetics for inducing or sensitizing cells to the induction of apoptotic cell death. Thus, compounds of the invention are useful in the treatment, amelioration, or prevention of hyperproliferative diseases such as cancer.
Public/Granted literature
- US20120263675A1 BIVALENT DIAZO BICYCLIC SMAC Public/Granted day:2012-10-18
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