Invention Grant
US08816062B2 Maleimide-furanyl compounds that can be used in a general method for preparing maleimide-oligonucleotide derivatives
有权
可用于制备马来酰亚胺 - 寡核苷酸衍生物的通用方法中的马来酰亚胺呋喃基化合物
- Patent Title: Maleimide-furanyl compounds that can be used in a general method for preparing maleimide-oligonucleotide derivatives
- Patent Title (中): 可用于制备马来酰亚胺 - 寡核苷酸衍生物的通用方法中的马来酰亚胺呋喃基化合物
-
Application No.: US13816841Application Date: 2011-05-02
-
Publication No.: US08816062B2Publication Date: 2014-08-26
- Inventor: Ana María Grandas Sagarra , Albert Sánchez González , Enrique Pedroso Muller
- Applicant: Ana María Grandas Sagarra , Albert Sánchez González , Enrique Pedroso Muller
- Applicant Address: ES Barcelona
- Assignee: Universitat de Barcelona
- Current Assignee: Universitat de Barcelona
- Current Assignee Address: ES Barcelona
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Priority: ES201031290 20100827
- International Application: PCT/ES2011/070311 WO 20110502
- International Announcement: WO2012/025646 WO 20120301
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07F9/6561 ; C07H1/00 ; C07D491/08
Abstract:
The compounds of formula (I) substantially in exo form or salts thereof, wherein: X is a biradical selected from —(CH2)n—*, —(CH2CH2O)nCH2CH2—*, methylcyclohexyl and methylphenyl; n is an integer ranging between 1 and 30; Y is a radical selected from —COOH, a substituted phosphoramidite radical and N-hydroxysuccinimide ester (or other active ester) of carboxylic acid; and * represents the place through which X binds to Y, are useful in a general process for solid-phase preparation of maleimide-oligonucleotide derivatives.
Public/Granted literature
Information query
