Invention Grant
US08816072B2 Process for the preparation of crystalline aprepitant having form I content
有权
制备具有I型含量的结晶阿拉米特的方法
- Patent Title: Process for the preparation of crystalline aprepitant having form I content
- Patent Title (中): 制备具有I型含量的结晶阿拉米特的方法
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Application No.: US13375548Application Date: 2010-06-02
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Publication No.: US08816072B2Publication Date: 2014-08-26
- Inventor: Deepak Mohanlal Jain , Maneck Khurana , Hiten Sharadchandra Mehta , Abhay Tatiya , Asok Nath , Sanjay Mahadeo Gade , Mohan Prasad , Subhash Dhar
- Applicant: Deepak Mohanlal Jain , Maneck Khurana , Hiten Sharadchandra Mehta , Abhay Tatiya , Asok Nath , Sanjay Mahadeo Gade , Mohan Prasad , Subhash Dhar
- Applicant Address: IN New Delhi
- Assignee: Ranbaxy Laboratories Limited
- Current Assignee: Ranbaxy Laboratories Limited
- Current Assignee Address: IN New Delhi
- Priority: IN1128/DEL/2009 20090602
- International Application: PCT/IB2010/052471 WO 20100602
- International Announcement: WO2010/140132 WO 20101209
- Main IPC: C07D413/06
- IPC: C07D413/06
Abstract:
The present invention provides a process for preparation of crystalline aprepitant having not more than 15% by weight of Form I content which comprises, a) dissolving aprepitant in a suitable solvent to obtain a solution, b) cooling the solution to 10-15° C., c) optionally seeding the solution with aprepitant Form I crystals, d) adding an anti-solvent to the solution, and e) isolating crystalline aprepitant having not more than 15% by weight of Form I content.
Public/Granted literature
- US20120277426A1 PROCESS FOR THE PREPARATION OF CRYSTALLINE APREPITANT HAVING FORM I CONTENT Public/Granted day:2012-11-01
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