Invention Grant
US08816074B2 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
有权
2'-氟-6'-亚甲基碳环核苷和治疗病毒感染的方法
- Patent Title: 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
- Patent Title (中): 2'-氟-6'-亚甲基碳环核苷和治疗病毒感染的方法
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Application No.: US13107713Application Date: 2011-05-13
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Publication No.: US08816074B2Publication Date: 2014-08-26
- Inventor: Chung K. Chu , Jianing Wang
- Applicant: Chung K. Chu , Jianing Wang
- Applicant Address: US GA Athens
- Assignee: University of Georgia Foundation, Inc.
- Current Assignee: University of Georgia Foundation, Inc.
- Current Assignee Address: US GA Athens
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: C07D473/34
- IPC: C07D473/34 ; C07D473/30 ; C07D239/54 ; C07D239/545 ; C07D239/553 ; C07D239/557 ; C07D239/47
Abstract:
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses.
Public/Granted literature
- US20110244027A1 2'-Fluoro-6'-Methylene Carbocyclic Nucleosides and Methods of Treating Viral Infections Public/Granted day:2011-10-06
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