Invention Grant
US08816083B2 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
有权
苯甲酸，苯甲酸衍生物和氢吗啡酮的杂芳基羧酸共轭物，前药，其制备方法和用途
- Patent Title: Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
- Patent Title (中): 苯甲酸，苯甲酸衍生物和氢吗啡酮的杂芳基羧酸共轭物，前药，其制备方法和用途
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Application No.: US13660112Application Date: 2012-10-25
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Publication No.: US08816083B2Publication Date: 2014-08-26
- Inventor: Travis Mickle , Sven Guenther , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- Applicant: KemPharm, Inc.
- Applicant Address: US IA Coralville
- Assignee: KemPharm, Inc.
- Current Assignee: KemPharm, Inc.
- Current Assignee Address: US IA Coralville
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: C07D489/02
- IPC: C07D489/02 ; A61K31/625
Abstract:
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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