A pepper hybrid designated E 490264 is disclosed. The invention relates to the seeds of pepper hybrid E 490264, to the plants of pepper hybrid E 490264, and to methods for producing a hybrid plant, either inbred or hybrid, by crossing the pepper hybrid E 490264 with itself or another pepper plant. The invention further relates to methods for producing a pepper plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other pepper lines, cultivars or hybrids derived from the pepper hybrid E 490264.