An RI manufacturing apparatus includes: an accelerator which accelerates charged particles; a target which is irradiated with the charged particle accelerated by the accelerator, thereby manufacturing a radioactive isotope; a built-in shield that may be a wall body which surrounds the accelerator and the target to shield radiation; and a target shield that may be a wall body which is disposed between the built-in shield and the accelerator and surrounds the target to shield the radiation.