Systems and methods for smudge control for touch screen human interface devices are provided. In one embodiment, a touch screen human interface device comprises: a touch sensitive display surface, the touch sensitive display surface including a first region having a first surface energy with respect to a contaminant material; and a pattern of a plurality of nucleation sites distributed within the first region, wherein each of the plurality of nucleation sites possesses a second surface energy that is higher than the first surface energy with respect to the contaminant material.