The present invention provides an uplink transmission method and apparatus in a wireless communication system. A terminal receives an uplink resource allocation from a base station; and transmits uplink transmission blocks to a PUSCH (physical uplink shared channel) by using the uplink resource allocation. The uplink resource allocation indicates an allocated RBs (resource blocks) within a subframe that includes a plurality of RBs. The subframe is divided into at least one PUCCH (physical uplink control channel) area for PUCCHs and a plurality of PUSCH (physical uplink shared channel) area for PUSCHs, wherein the PUCCH area is arranged between the plurality of PUSCH regions.