In a wireless communication network where base stations receive protocol data units (PDUs) from mobile stations for decompression and deciphering for ordered, sequential transfer as service data units (SDUs) to an associated core network, the teachings presented herein provide a method of supporting seamless handover of a mobile station from a source base station to a target base station. By way of example, the teachings herein apply to a network based on the E-UTRA specifications, as promulgated by the 3GPP. However, that example is non-limiting, as the teachings herein apply to any network that employs in-sequence data delivery and duplicate data detection at handover. Broadly, the source base station forwards out-of-sequence SDUs and corresponding sequence number information to the target base station in support of seamless handover, and the target base station uses that information to request retransmissions as needed for packet reordering.