A system and a method are provided for configuring the touch-sensitive area and/or the tap duration associated with a plurality of touch-sensitive soft buttons of a vehicle user interface in response to varying vehicle conditions. In particular, as a monitored vehicle condition deteriorates, the system controller coupled to the vehicle user interface expands the touch-sensitive region and/or increases the tap duration of the touch-sensitive soft buttons, thereby improving the user's ability to successfully interact with the interface. Vehicle conditions that may be monitored and used to configure the touch-sensitive area and/or tap duration include passenger cabin vibration levels, vehicle speed, turn radius, lateral force levels, precipitation levels and external ambient temperature.