Methods and systems for performing load balancing and session persistence in IP (e.g., IPv6) networks are described herein. Some aspects relate to a destination options extension header that may be defined as a load balancing session persistence option (LBSPO) for storing a client identifier and a server identifier for each of a client and a server during a session. Packets sent between the client and the server may include the LBSPO with the client and server identifiers. A load balancer with a virtual IP address of a target application can perform session persistence and assign a destination server to a client based on a preexisting session between the server and the client, as determined by the LBSPO information. While a target VIP node may process data packets based on the LBSPO information, once established, the LBSPO information may remain unchanged for the duration of the session.