The subject invention provides a unique interactive system and method that facilitate single-handed navigation and interaction with applications within a display space on any type of mobile computing device. The system and method include or employ scalable application tiles corresponding to applications, whereby the application tiles can provide or indicate the current state of the corresponding application. The state information provided in each tile can vary as well depending on the current size of the tile. The tiles can be arranged into a plurality of zones such that a user can view one particular zone at a time and obtain more context and information from the application tiles in that zone rather than working with all tiles and all zones at the same time. The view of the display space can be of the world or all application tiles, zone, or application. Panning and zooming among the zones, application tiles and/or views can be performed single-handedly using designated on or off screen controls.