A medication delivery system for delivering medication to an internal body cavity through a natural body orifice that opens to the cavity has a pad for external placement against the body orifice and an elongated body that extends from the pad through the body orifice when the pad is externally placed against the body orifice. The elongated body carries medication and is long enough to deliver the carried medication to tissue forming the body cavity. The pad has a medication-holding zone surrounding the elongated body on an inner face of the pad and carrying medication that is delivered externally to tissue surrounding the body orifice concurrent with delivery of the medication carried by the elongated body to the tissue forming the body cavity.