A surgical system having feedback control for pneumatic actuators includes a pneumatic pressure source and a vitrectomy cutter having a cutting mechanism, a first pneumatic input port, and a second pneumatic input port. A pneumatic actuator is configured to direct pneumatic pressure to one of the first and second pneumatic input ports. A first pressure transducer is located and configured to detect actual pressure at the first pneumatic input port, and a second pressure transducer is located and configured to detect actual pressure at the second pneumatic input port. A controller communicates with the first and second pressure transducers and the pneumatic actuator. It is configured to change the pneumatic actuator actuation timing based on the data communicated from the first and second pressure transducers.