A test strip reader for reading a test result of a test strip plate or cassette is provided. The test strip plate or cassette includes a test strip and is configured for generating a control line or a test line in the test strip according to the test result. The test strip plate or cassette reader includes a light source, a driver configured for driving the light source to emit light to a section of the test strip corresponding to the control line or the test line, a photo detector configured for receiving light reflected from the section and generating a detecting signal corresponding to the test result, a signal processor configured for processing the detecting signal to obtain the test result and generating a corresponding result signal, and a display configured to display the test result based upon the result signal.