Invention Grant
US08821875B2 Pharmaceutical composition comprising antibodies against catalase and superoxide dismutase for tumor therapy
有权
药物组合物包含抗过氧化氢酶和超氧化物歧化酶用于肿瘤治疗的抗体
- Patent Title: Pharmaceutical composition comprising antibodies against catalase and superoxide dismutase for tumor therapy
- Patent Title (中): 药物组合物包含抗过氧化氢酶和超氧化物歧化酶用于肿瘤治疗的抗体
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Application No.: US14119177Application Date: 2012-06-15
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Publication No.: US08821875B2Publication Date: 2014-09-02
- Inventor: Georg Bauer
- Applicant: Georg Bauer
- Applicant Address: DE Freiburg
- Assignee: Universitaetsklinikum Freiburg
- Current Assignee: Universitaetsklinikum Freiburg
- Current Assignee Address: DE Freiburg
- Agency: Smith Patent
- Agent Chalin A. Smith
- Priority: EP11170076 20110616
- International Application: PCT/EP2012/061393 WO 20120615
- International Announcement: WO2012/172034 WO 20121220
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/40 ; C07K16/30 ; A61K39/00
Abstract:
The present invention is based on the unexpected finding that, in addition to catalase, SOD is also involved in protecting tumor cells, wherein the inhibition effects of the two protective enzymes support one another in a complementary manner. The invention thus relates to pharmaceutical compositions containing at least two antibodies or the biologically active fragments thereof, wherein the one antibody is directed against the catalase and the other antibody is directed against the superoxide dismutase, as well as their use for treating a tumor disease.
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