Invention Grant
US08822142B2 Analysis of single biological cells 有权
单一生物细胞分析

  • Patent Title: Analysis of single biological cells
  • Patent Title (中): 单一生物细胞分析
  • Application No.: US12734988
    Application Date: 2008-12-09
  • Publication No.: US08822142B2
    Publication Date: 2014-09-02
  • Inventor: Sören-Oliver Deininger
  • Applicant: Sören-Oliver Deininger
  • Applicant Address: DE Bremen
  • Assignee: Bruker Daltonik GmbH
  • Current Assignee: Bruker Daltonik GmbH
  • Current Assignee Address: DE Bremen
  • Agent Paul Vincent
  • Priority: DE102007060438 20071214
  • International Application: PCT/EP2008/010421 WO 20081209
  • International Announcement: WO2009/077106 WO 20090625
  • Main IPC: C12Q1/00
  • IPC: C12Q1/00 H01J49/16
Analysis of single biological cells
Abstract:
An analysis of type, state or other distinguishing features of individual cells from body fluids, smears or tissues includes the steps of depositing the cells, with a minimum possible overlap, on a mass spectrometric sample support, determining the coordinates of the cells, coating the sample support with a layer of small crystals of a matrix substance, positioning the cells, inside a mass spectrometer, according to their known coordinates with a movement device into the position of the laser focus, acquiring mass spectra of the individual cells with ionization of the cell components by matrix assisted laser desorption, and using the mass spectra for an analysis of type, state or other distinguishing features of the cells.
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