Invention Grant
US08822185B2 Peroxisome biogenesis factor protein (PEX) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms
有权
过氧化物酶体生物因子蛋白（PEX）改变多不饱和脂肪酸和油脂真核生物中总脂质含量的破坏
- Patent Title: Peroxisome biogenesis factor protein (PEX) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms
- Patent Title (中): 过氧化物酶体生物因子蛋白（PEX）改变多不饱和脂肪酸和油脂真核生物中总脂质含量的破坏
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Application No.: US13780532Application Date: 2013-02-28
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Publication No.: US08822185B2Publication Date: 2014-09-02
- Inventor: Seung-Pyo Hong , Pamela L Sharpe , Zhixiong Xue , Narendra S Yadav , Quinn Qun Zhu
- Applicant: E I Du Pont De Nemours and Company
- Applicant Address: US DE Wilmington
- Assignee: E I du Pont de Nemours and Company
- Current Assignee: E I du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Main IPC: C12P7/64
- IPC: C12P7/64 ; C12P1/00 ; C12N9/10 ; C12N9/02 ; C12N15/81
Abstract:
Methods of increasing the amount of polyunsaturated fatty acids (PUFAs) in the total lipid fraction and in the oil fraction of PUFA-producing, oleaginous eukaryotes, accomplished by modifying the activity of peroxisome biogenesis factor (Pex) proteins, are disclosed. Disruptions of a chromosomal Pex3 gene, Pex10p gene or Pex16p gene in a PUFA-producing, oleaginous eukaryotic strain resulted in an increased amount of PUFAs, as a percent of total fatty acids and as a percent of dry cell weight, in the total lipid fraction and in the oil fraction of the strain, as compared to the parental strain whose native Pex protein was not disrupted.
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