Invention Grant
US08822195B2 Polypeptide having D-lactate dehydrogenase activity, polynucleotide encoding the polypeptide, and process for production of D-lactic acid
有权
具有D-乳酸脱氢酶活性的多肽，编码多肽的多核苷酸，以及D-乳酸的生产方法
- Patent Title: Polypeptide having D-lactate dehydrogenase activity, polynucleotide encoding the polypeptide, and process for production of D-lactic acid
- Patent Title (中): 具有D-乳酸脱氢酶活性的多肽，编码多肽的多核苷酸，以及D-乳酸的生产方法
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Application No.: US13375882Application Date: 2010-06-02
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Publication No.: US08822195B2Publication Date: 2014-09-02
- Inventor: Kenji Sawai , Kazumi Suda , Hideki Sawai , Katsushige Yamada , Junya Yamagishi
- Applicant: Kenji Sawai , Kazumi Suda , Hideki Sawai , Katsushige Yamada , Junya Yamagishi
- Applicant Address: JP
- Assignee: Toray Industries, Inc.
- Current Assignee: Toray Industries, Inc.
- Current Assignee Address: JP
- Agency: DLA Piper LLP (US)
- Priority: JP2009-134213 20090603
- International Application: PCT/JP2010/059306 WO 20100602
- International Announcement: WO2010/140602 WO 20101209
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12N15/00 ; C12N9/04 ; C12P7/56
Abstract:
Highly productive D-lactic acid fermentation uses a transformant obtained by introducing into a host cell a polynucleotide encoding a polypeptide according to any one of the following (A) to (C) in such a manner that the polypeptide is expressed, which polypeptide has a D-lactate dehydrogenase activity higher than those of conventional polypeptides: (A) a polypeptide having the amino acid sequence shown in SEQ ID NO:1 or 2; (B) a polypeptide having the same amino acid sequence as shown in SEQ ID NO:1 or 2 except that one or several amino acids are substituted, deleted, inserted and/or added, which polypeptide has a D-lactate dehydrogenase activity; and (C) a polypeptide having an amino acid sequence which has a sequence identity of not less than 80% to the amino acid sequence shown in SEQ ID NO:1 or 2, which polypeptide has a D-lactate dehydrogenase activity.
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