Invention Grant
US08822196B2 Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
有权
抗血管内皮生长因子受体-2嵌合抗原受体及其用途，用于治疗癌症
- Patent Title: Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
- Patent Title (中): 抗血管内皮生长因子受体-2嵌合抗原受体及其用途，用于治疗癌症
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Application No.: US13875560Application Date: 2013-05-02
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Publication No.: US08822196B2Publication Date: 2014-09-02
- Inventor: Steven A. Rosenberg , Dhanalakshmi Chinnasamy
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C12N15/62
- IPC: C12N15/62 ; C07K14/705 ; C07K16/28 ; C12N15/63 ; C12N15/79
Abstract:
The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
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