Invention Grant
- Patent Title: Bispecific intracellular delivery vehicles
- Patent Title (中): 双特异性细胞内递送载体
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Application No.: US13127968Application Date: 2009-05-13
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Publication No.: US08822213B2Publication Date: 2014-09-02
- Inventor: Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
- Applicant: Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
- Applicant Address: US WA Seattle US WA Seattle
- Assignee: University of Washington,PhaseRx, Inc.
- Current Assignee: University of Washington,PhaseRx, Inc.
- Current Assignee Address: US WA Seattle US WA Seattle
- Agency: Christensen O'Connor Johnson Kindness PLLC
- International Application: PCT/US2009/043852 WO 20090513
- International Announcement: WO2010/053596 WO 20100514
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/07 ; A61K47/48 ; C07K16/46 ; C07K16/32 ; C07K16/28 ; C07K16/18
Abstract:
A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
Public/Granted literature
- US20110281354A1 BISPECIFIC INTRACELLULAR DELIVERY VEHICLES Public/Granted day:2011-11-17
Information query
