Invention Grant
US08822216B2 DNA regulatory element for the expression of transgenes in neurons of a subject and uses thereof
有权
用于在受试者的神经元中表达转基因的DNA调节元件及其用途
- Patent Title: DNA regulatory element for the expression of transgenes in neurons of a subject and uses thereof
- Patent Title (中): 用于在受试者的神经元中表达转基因的DNA调节元件及其用途
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Application No.: US13409066Application Date: 2012-02-29
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Publication No.: US08822216B2Publication Date: 2014-09-02
- Inventor: Eric R. Kandel , Mark Mayford
- Applicant: Eric R. Kandel , Mark Mayford
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/10 ; C12N5/16 ; C12N5/0793
Abstract:
The present invention provides for a method of evaluating whether a compound is effective in activating a calcium-calmodulin dependent kinase IIα promoter in a human neuronal cell which comprises: (a) contacting the human neuronal cell which has been stably transformed by a recombinant nucleic acid molecule comprising a gene of interest operatively linked to a nucleic acid encoding a calcium-calmodulin dependent kinase IIα promoter which has a nucleotide sequence of the promoter in ATCC Accession No. 98582 with the compound, and (b) comparing the expression level of the gene of interest in the neuronal cell in step (a) with the level in the neuronal cell in the absence of the compound, thereby determining whether the compound is effective in activating the calcium-calmodulin dependent kinase IIα promoter.
Public/Granted literature
- US20120294805A1 DNA regulatory element for the expression of transgenes in neurons of a subject and uses thereof Public/Granted day:2012-11-22
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