Invention Grant
- Patent Title: Membrane resident peptide in anti-cancer peptides causes tumor cell necrosis rather than apoptosis of cancer cells
- Patent Title (中): 抗癌肽中的膜驻留肽引起肿瘤细胞坏死而不是癌细胞凋亡
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Application No.: US13122256Application Date: 2009-10-02
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Publication No.: US08822419B2Publication Date: 2014-09-02
- Inventor: Matthew R. Pincus , Josef Michl , Ehsan Sarafraz-Yazdi
- Applicant: Matthew R. Pincus , Josef Michl , Ehsan Sarafraz-Yazdi
- Applicant Address: US NY Albany
- Assignee: The Research Foundation of State University of New York
- Current Assignee: The Research Foundation of State University of New York
- Current Assignee Address: US NY Albany
- Agency: Hoffmann & Baron, LLP
- International Application: PCT/US2009/059380 WO 20091002
- International Announcement: WO2010/040051 WO 20100408
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell; and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form.
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