Invention Grant
US08822445B2 Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof 有权
碳青霉烯衍生物或其水合物的结晶形式及其制备方法和用途

  • Patent Title: Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof
  • Patent Title (中): 碳青霉烯衍生物或其水合物的结晶形式及其制备方法和用途
  • Application No.: US13701704
    Application Date: 2011-06-01
  • Publication No.: US08822445B2
    Publication Date: 2014-09-02
  • Inventor: Zhenhua HuangYanyan Dong
  • Applicant: Zhenhua HuangYanyan Dong
  • Applicant Address: CN Jinan, Shandong Province
  • Assignee: Xuanzhu Pharma Co., Ltd.
  • Current Assignee: Xuanzhu Pharma Co., Ltd.
  • Current Assignee Address: CN Jinan, Shandong Province
  • Agency: Clark & Elbing LLP
  • Priority: CN201010190636 20100603; CN201110104082 20110425
  • International Application: PCT/CN2011/000925 WO 20110601
  • International Announcement: WO2011/150679 WO 20111208
  • Main IPC: A61K31/397
  • IPC: A61K31/397 C07D477/20 A61K31/407
Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof
Abstract:
The present invention relates to the crystalline form of carbapenems derivative or hydrate thereof and the preparation methods thereof. Specifically, the present invention relates to the crystalline form of carbapenem derivative (4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((4-sulfamoylbenzyl)carbamoyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid as represented by formula (I) or hydrate thereof, characterized in that the X-ray powder diffraction pattern thereof using Cu-Ka radiation represented as 2θ has characteristic peaks at 18.9±0.2, 19.4±0.2, 21.0±0.2, 21.7±0.2, and 23.4±0.2, the preparation methods thereof, and the use thereof in the preparation of medicament for treating and/or preventing infectious diseases, as well as a pharmaceutical composition comprising such compound and one or more pharmaceutical carriers and/or diluents.
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