Invention Grant
- Patent Title: Bisfluoroalkyl-1,4-benzodiazepinone compounds
- Patent Title (中): 双氟烷基-1,4-苯并二氮杂酮化合物
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Application No.: US14100896Application Date: 2013-12-09
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Publication No.: US08822454B2Publication Date: 2014-09-02
- Inventor: Ashvinikumar V. Gavai , Claude A. Quesnelle , Soong-Hoon Kim
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- Main IPC: C07D243/24
- IPC: C07D243/24 ; A61K31/5513 ; A61K31/337 ; A61K31/138 ; A61K45/06 ; A61K31/555 ; A61K31/573

Abstract:
Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is —CH2CF3 or —CH2CH2CF3; R2 is —CH2CF3, —CH2CH2CF3, or —CH2CH2CH2CF3; R3 is H or —CH3; each Ra is independently F, Cl, —CN, —OCH3, and/or —NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US20140100365A1 BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS Public/Granted day:2014-04-10
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