Invention Grant
US08822464B2 N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
有权
N-芳基 - 哌嗪衍生物及其作为mGluR5受体的正变构调节剂的用途
- Patent Title: N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
- Patent Title (中): N-芳基 - 哌嗪衍生物及其作为mGluR5受体的正变构调节剂的用途
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Application No.: US13684606Application Date: 2012-11-26
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Publication No.: US08822464B2Publication Date: 2014-09-02
- Inventor: Matthias Grauert , Daniel Bischoff , Georg Dahmann , Raimund Kuelzer , Klaus Rudolf
- Applicant: Matthias Grauert , Daniel Bischoff , Georg Dahmann , Raimund Kuelzer , Klaus Rudolf
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Anthony P. Bottino
- Priority: EP11190971 20111128
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/52 ; C07D231/12 ; C07D473/34 ; C07D401/12 ; C07D403/12 ; C07D401/14 ; C07D403/14 ; A61K31/53 ; C07D409/14 ; C07D401/06 ; C07D413/14
Abstract:
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.
Public/Granted literature
- US20130137688A1 NOVEL COMPOUNDS Public/Granted day:2013-05-30
Information query
IPC分类:
