Invention Grant
- Patent Title: Piperidine and piperazine derivatives as autotaxin inhibitors
- Patent Title (中): 哌啶和哌嗪衍生物作为自分泌抑素
-
Application No.: US13258068Application Date: 2010-03-03
-
Publication No.: US08822476B2Publication Date: 2014-09-02
- Inventor: Kai Schiemann , Melanie Schultz , Wolfgang Staehle
- Applicant: Kai Schiemann , Melanie Schultz , Wolfgang Staehle
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP09004856 20090402
- International Application: PCT/EP2010/001323 WO 20100303
- International Announcement: WO2010/115491 WO 20101014
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/445 ; C07D403/04 ; C07D403/08 ; C07D261/20 ; C07D211/32
Abstract:
The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
Public/Granted literature
- US20120059016A1 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS Public/Granted day:2012-03-08
Information query
IPC分类:
