Invention Grant
US08822478B2 Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
有权
WNT信号通路的吲唑抑制剂及其治疗用途
- Patent Title: Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
- Patent Title (中): WNT信号通路的吲唑抑制剂及其治疗用途
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Application No.: US13552188Application Date: 2012-07-18
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Publication No.: US08822478B2Publication Date: 2014-09-02
- Inventor: John Hood , David Mark Wallace , Sunil Kumar KC
- Applicant: John Hood , David Mark Wallace , Sunil Kumar KC
- Applicant Address: US CA San Diego
- Assignee: Samumed, LLC
- Current Assignee: Samumed, LLC
- Current Assignee Address: US CA San Diego
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/505
- IPC: A61K31/505 ; A61K31/44
Abstract:
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
Public/Granted literature
- US20130040976A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF Public/Granted day:2013-02-14
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