Invention Grant
- Patent Title: Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof
- Patent Title (中): 盐酸伊替替，合成，结晶形式，药物组合物及其用途
-
Application No.: US13003216Application Date: 2009-07-07
-
Publication No.: US08822482B2Publication Date: 2014-09-02
- Inventor: Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
- Applicant: Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
- Applicant Address: US CT Branford
- Assignee: Beta Pharma, Inc.
- Current Assignee: Beta Pharma, Inc.
- Current Assignee Address: US CT Branford
- Agency: Fox Rothschild LLP
- Agent Wansheng Jerry Liu
- Priority: CN200810132631 20080708; CN200810132458 20080717; CN200810188272 20081223
- International Application: PCT/CN2009/000773 WO 20090707
- International Announcement: WO2010/003313 WO 20100114
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D491/056
Abstract:
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
Public/Granted literature
- US20110182882A1 Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof Public/Granted day:2011-07-28
Information query
IPC分类:
