Invention Grant
US08822504B2 5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanomethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as NK1 receptor antagonists
有权
5- [5- [2-（3,5-双（三氟甲基）苯基）-2-甲基丙酰甲基丙酰基甲基氨基] -4-（4-氟-2-甲基苯基）] - 2-吡啶基-2-烷基 - 脯氨酰胺作为NK1受体 拮抗剂
![5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanomethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as NK1 receptor antagonists](/docs/US/2014-09-02/US08822504B2/abs.jpg.600x600.jpg)
- Patent Title: 5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanomethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as NK1 receptor antagonists
- Patent Title (中): 5- [5- [2-（3,5-双（三氟甲基）苯基）-2-甲基丙酰甲基丙酰基甲基氨基] -4-（4-氟-2-甲基苯基）] - 2-吡啶基-2-烷基 - 脯氨酰胺作为NK1受体 拮抗剂
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Application No.: US13681925Application Date: 2012-11-20
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Publication No.: US08822504B2Publication Date: 2014-09-02
- Inventor: Giuseppe Alvaro , Agostino Marasco
- Applicant: Nerre Therapeutics Limited
- Applicant Address: GB London
- Assignee: Nerre Therapeutics Limited
- Current Assignee: Nerre Therapeutics Limited
- Current Assignee Address: GB London
- Agency: Steinfl & Bruno, LLP
- Priority: GB0808747.0 20080514
- Main IPC: A61K31/4439
- IPC: A61K31/4439
![5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanomethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as NK1 receptor antagonists](/abs-image/US/2014/09/02/US08822504B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R is C1-4 alkyl useful in the treatment of diseases and conditions for which antagonism of NK1 receptor is beneficial.
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