Invention Grant
- Patent Title: Substituted 3-phenyl-1,2,4-Oxadiazole compounds
- Patent Title (中): 取代的3-苯基-1,2,4-恶二唑化合物
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Application No.: US13811032Application Date: 2011-07-20
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Publication No.: US08822510B2Publication Date: 2014-09-02
- Inventor: Jagabandhu Das , Soo S. Koo , Anurag S. Srivastava , Robert V. Moquin , Scott Hunter Watterson
- Applicant: Jagabandhu Das , Soo S. Koo , Anurag S. Srivastava , Robert V. Moquin , Scott Hunter Watterson
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2011/044597 WO 20110720
- International Announcement: WO2012/012477 WO 20120126
- Main IPC: C07D413/10
- IPC: C07D413/10 ; C07D413/14 ; C07D413/08 ; C07D413/06 ; C07D271/06 ; A61K31/454 ; A61K31/4439 ; A61K31/4245 ; C07D487/10

Abstract:
Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C1-C4 alkyl, or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C1-6alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.
Public/Granted literature
- US20130158001A1 SUBSTITUTED 3-PHENYL-1,2,4-OXADIAZOLE COMPOUNDS Public/Granted day:2013-06-20
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