Invention Grant
- Patent Title: Substituted aminopropionic derivatives as neprilysin inhibitors
- Patent Title (中): 取代的氨基丙酸衍生物作为尿丙氨酸抑制剂
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Application No.: US13688630Application Date: 2012-11-29
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Publication No.: US08822534B2Publication Date: 2014-09-02
- Inventor: Yuki Iwaki , Rajeshri Ganesh Karki , Gary Michael Ksander
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Sophie Binet Cross
- Main IPC: A61K31/235
- IPC: A61K31/235 ; C07C229/34
Abstract:
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Public/Granted literature
- US20130096127A1 SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS Public/Granted day:2013-04-18
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