Invention Grant
US08822647B2 Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
有权
使用嵌合抗原受体的增强T细胞抗肿瘤效应子功能的方法和组合物
- Patent Title: Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
- Patent Title (中): 使用嵌合抗原受体的增强T细胞抗肿瘤效应子功能的方法和组合物
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Application No.: US13060908Application Date: 2009-08-26
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Publication No.: US08822647B2Publication Date: 2014-09-02
- Inventor: Michael Jensen
- Applicant: Michael Jensen
- Applicant Address: US CA Duarte
- Assignee: City of Hope
- Current Assignee: City of Hope
- Current Assignee Address: US CA Duarte
- Agency: Rothwell, Figg, Ernst & Manbeck P.C.
- International Application: PCT/US2009/055029 WO 20090826
- International Announcement: WO2010/025177 WO 20100304
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K19/00 ; C12N5/0783 ; C12N5/22 ; C12N15/63 ; A61P35/00
Abstract:
Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.
Public/Granted literature
- US20120148552A1 METHOD AND COMPOSITIONS FOR ENHANCED ANTI-TUMOR EFFECTOR FUNCTIONING OF T CELLS Public/Granted day:2012-06-14
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