Invention Grant
- Patent Title: Monoclonal antibodies that bind B7H6 and uses thereof
- Patent Title (中): 结合B7H6的单克隆抗体及其用途
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Application No.: US13515276Application Date: 2010-12-08
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Publication No.: US08822652B2Publication Date: 2014-09-02
- Inventor: Michel Pierres , Eric Vivier , Myriam Baratin
- Applicant: Michel Pierres , Eric Vivier , Myriam Baratin
- Applicant Address: FR Paris
- Assignee: Institut National de la Sante et de la Recherche Medicale
- Current Assignee: Institut National de la Sante et de la Recherche Medicale
- Current Assignee Address: FR Paris
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jeanne M. DiGiorgio
- International Application: PCT/IB2010/003411 WO 20101208
- International Announcement: WO2011/070443 WO 20110616
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395
Abstract:
Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells.
Public/Granted literature
- US20130004432A1 MONOCLONAL ANTIBODIES THAT BIND B7H6 AND USES THEREOF Public/Granted day:2013-01-03
Information query
