Invention Grant
- Patent Title: 2'-O-modified RNA
- Patent Title (中): 2'-O-修饰的RNA
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Application No.: US13990441Application Date: 2011-11-28
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Publication No.: US08822671B2Publication Date: 2014-09-02
- Inventor: Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
- Applicant: Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
- Applicant Address: JP Tokyo JP Okinawa
- Assignee: The University of Tokyo,Chiralgen, Ltd.
- Current Assignee: The University of Tokyo,Chiralgen, Ltd.
- Current Assignee Address: JP Tokyo JP Okinawa
- Agency: Osha Liang LLP
- International Application: PCT/JP2011/077313 WO 20111128
- International Announcement: WO2012/073857 WO 20120607
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H19/10 ; C07H23/00 ; C07H19/06 ; C07H1/00 ; C07H19/067 ; C07H19/167

Abstract:
A 2′-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.
Public/Granted literature
- US20130253178A1 2'-O-MODIFIED RNA Public/Granted day:2013-09-26
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