Invention Grant
- Patent Title: Method for synthesizing temsirolimus
- Patent Title (中): 替西罗莫司的合成方法
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Application No.: US13933118Application Date: 2013-07-01
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Publication No.: US08822678B2Publication Date: 2014-09-02
- Inventor: Honghai Song , Long Tang , Wei Chen , Zheng Li , Jinzhou Li , Zhicun Sun , Jiajin Feng
- Applicant: Tianjin Weijie Technology Co., Ltd.
- Applicant Address: CN Tianjin
- Assignee: Tianjin Wiejie Technology Co., Ltd.
- Current Assignee: Tianjin Wiejie Technology Co., Ltd.
- Current Assignee Address: CN Tianjin
- Agency: Matthias Scholl P.C.
- Agent Matthias Scholl
- Priority: CN201110002891 20110107
- Main IPC: C07D498/22
- IPC: C07D498/22 ; C07D498/18 ; C07F5/02
Abstract:
A method for synthesizing temsirolimus, the method including: using a substituted boric acid to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out a reaction between the intermediate II and 2,4,6-trichlorobenzoyl chloride; carrying out condensation reaction between a resulting product and rapamycin to produce intermediate III; and finally using a diol to remove a protecting group from the intermediate III to yield temsirolimus.
Public/Granted literature
- US20130296550A1 METHOD FOR SYNTHESIZING TEMSIROLIMUS Public/Granted day:2013-11-07
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