A system and tuning method to collaboratively calibrate high voltage DAC values and Photomultiplier Tube DAC values of photomultiplier tubes of a gamma camera so that the detector produces a valid energy spectrum over the entire detector surface. A method for tuning a gamma camera having a plurality of photosensors, exposes the photosensors to scintillation photons corresponding to nuclear radiation of known energy; measures an energy output corresponding to each specific photosensor; calculates an average enemy output of all photosensors in the camera; collaboratively adjusts a DAC value corresponding to a voltage applied to a specific photosensor and a DACHV value corresponding to a high voltage applied to the camera based on the calculated average energy, energy output of each photosensor, and a target energy value corresponding to said known energy; and repeats the calibration until convergence is achieved between the average energy, energy output, and target energy.