A system and method for adjusting a common mode output voltage in an instrumentation amplifier is provided. In one aspect, the common mode output voltage is increased or decreased with respect to the common mode input voltage to enable high amplification of the signal input to the instrumentation amplifier. Moreover, the common mode output voltage can be driven to (or approximately to) a target voltage value such as, but not limited to, half the supply, even if the common mode input voltage is close to supply or ground rail voltage. Thus, a high amplification of the differential input voltage can be obtained and utilized for various applications requiring rail to rail input.