A multiple time domain synchronizer includes a data pipeline containing a plurality of serially-connected delay elements therein. A latency selection circuit is provided, which has a plurality of inputs electrically coupled to outputs of a corresponding plurality of delay elements in the data pipeline. The latency selection circuit is configured to pass a data pipeline signal from an output of a selected one of the plurality of delay elements in response to a latency control signal. A synchronization circuit is provided, which is electrically coupled to an output of the latency selection circuit. This synchronization circuit, which includes first and second unequal timing paths therein, is responsive to a clock that synchronizes capture of the data pipeline signal selected by the latency selection circuit and a destination code that selects one of the first and second unequal timing paths to be traversed by the captured data pipeline signal as active.