Invention Grant
- Patent Title: Chimaeric protein
- Patent Title (中): 嵌合蛋白
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Application No.: US13382119Application Date: 2010-07-05
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Publication No.: US08828407B2Publication Date: 2014-09-09
- Inventor: Paul Britton , Erica Bickerton , Maria Armesto
- Applicant: Paul Britton , Erica Bickerton , Maria Armesto
- Applicant Address: GB Pirbright
- Assignee: The Pirbright Institute
- Current Assignee: The Pirbright Institute
- Current Assignee Address: GB Pirbright
- Agency: Marshall, Gerstein & Borun LLP
- Priority: GB0911794.6 20090707
- International Application: PCT/GB2010/001293 WO 20100705
- International Announcement: WO2011/004146 WO 20110113
- Main IPC: A61K39/215
- IPC: A61K39/215 ; C12N7/01 ; C12N7/02 ; C12N5/10 ; C12N15/50 ; C07K19/00 ; C07K14/165
Abstract:
The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
Public/Granted literature
- US20120177675A1 Chimaeric Protein Public/Granted day:2012-07-12
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