Invention Grant
US08828937B2 Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity
有权
具有降低的BMP拮抗剂敏感性的骨形态发生蛋白2（BMP2）变体
- Patent Title: Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity
- Patent Title (中): 具有降低的BMP拮抗剂敏感性的骨形态发生蛋白2（BMP2）变体
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Application No.: US13255909Application Date: 2010-03-11
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Publication No.: US08828937B2Publication Date: 2014-09-09
- Inventor: Petra Seemann , Stefan Mundlos , Carsten Reissner , Georg Duda , Julia Zimmer
- Applicant: Petra Seemann , Stefan Mundlos , Carsten Reissner , Georg Duda , Julia Zimmer
- Applicant Address: DE Alfeld (Leine)
- Assignee: Haase Investments UG
- Current Assignee: Haase Investments UG
- Current Assignee Address: DE Alfeld (Leine)
- Agency: Agris & von Natzmer LLP
- Agent Joyce von Natzmer
- Priority: EP09155049 20090312
- International Application: PCT/EP2010/053103 WO 20100311
- International Announcement: WO2010/103070 WO 20100916
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/435 ; C07K14/46 ; C07K14/465 ; C07K14/51 ; C12N15/00 ; C12N15/12 ; C12N15/63
Abstract:
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
Public/Granted literature
- US20120058944A1 BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY Public/Granted day:2012-03-08
Information query
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