Invention Grant
- Patent Title: Carbohydrate conjugates as delivery agents for oligonucleotides
- Patent Title (中): 碳水化合物缀合物作为寡核苷酸的递送剂
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Application No.: US13693478Application Date: 2012-12-04
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Publication No.: US08828956B2Publication Date: 2014-09-09
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev , Narayanannair K. Jayaprakash , Martin Maier
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; A61K47/48 ; C07H21/02

Abstract:
The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein: A and B are each independently for each occurrence O, N(RN) or S; X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)— or -Linker-R; R is LG, -Linker-LG, or has the structure shown below: LG is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide; RN is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl; and Z′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.
Public/Granted literature
- US20130178512A1 CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES Public/Granted day:2013-07-11
Information query
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