Invention Grant
- Patent Title: Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
- Patent Title (中): 苯酮，苯甲酸衍生物和氢可酮的杂芳基羧酸共轭物，前药，其制备方法和用途
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Application No.: US13888583Application Date: 2013-05-07
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Publication No.: US08828978B2Publication Date: 2014-09-09
- Inventor: Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- Applicant: KemPharm, Inc.
- Applicant Address: US IA Coralville
- Assignee: KemPharm, Inc.
- Current Assignee: KemPharm, Inc.
- Current Assignee Address: US IA Coralville
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61K31/485
Abstract:
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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