Invention Grant
US08828984B2 Gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection
有权
含有N-杂环卡宾配体的金（III）络合物，合成及其在癌症治疗和硫醇检测中的应用
- Patent Title: Gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection
- Patent Title (中): 含有N-杂环卡宾配体的金（III）络合物，合成及其在癌症治疗和硫醇检测中的应用
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Application No.: US14078742Application Date: 2013-11-13
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Publication No.: US08828984B2Publication Date: 2014-09-09
- Inventor: Chi Ming Che , Taotao Zou
- Applicant: University of Hong Kong
- Applicant Address: CN Hong Kong
- Assignee: The University of Hong Kong
- Current Assignee: The University of Hong Kong
- Current Assignee Address: CN Hong Kong
- Agency: Leason Ellis LLP
- Main IPC: A61K31/555
- IPC: A61K31/555 ; C07F1/12
Abstract:
Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.
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