Invention Grant
US08829000B2 Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors
有权
取代的咪唑并[1,5-A]喹喔啉,为磷酸二酯酶9抑制剂
- Patent Title: Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors
- Patent Title (中): 取代的咪唑并[1,5-A]喹喔啉,为磷酸二酯酶9抑制剂
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Application No.: US13617683Application Date: 2012-09-14
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Publication No.: US08829000B2Publication Date: 2014-09-09
- Inventor: Makoto Okada , Shuichiro Sato , Kenji Kawade , Kotaro Gotanda , Atsushi Shinbo , Youichi Nakano , Hideo Kobayashi
- Applicant: Makoto Okada , Shuichiro Sato , Kenji Kawade , Kotaro Gotanda , Atsushi Shinbo , Youichi Nakano , Hideo Kobayashi
- Applicant Address: JP Tokyo
- Assignee: ASKA Pharmaceutical Co., Ltd.
- Current Assignee: ASKA Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2006-336215 20061213
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D487/04 ; C07D487/14
![Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors](/abs-image/US/2014/09/09/US08829000B2/abs.jpg.150x150.jpg)
Abstract:
The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula, R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like, R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like, R4 stands for hydrogen, hydroxy, alkyl or amino, R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro, R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9, R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like, X stands for S or O, and A1, A2 and A3 each independently stands for N or C.
Public/Granted literature
- US20130225572A1 Substituted Imidazo[1,5-A]Quinoxalines As a PDE9 Inhibitor Public/Granted day:2013-08-29
Information query
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