Invention Grant
- Patent Title: Inhibitors of influenza viruses replication
- Patent Title (中): 流感病毒复制抑制剂
-
Application No.: US14098867Application Date: 2013-12-06
-
Publication No.: US08829007B2Publication Date: 2014-09-09
- Inventor: Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Bym , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann , Francesco G. Salituro , Ann Dak-Yee Kwong
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Andrew N. Weber; Jonathan P. O'Brien
- Main IPC: C07D239/12
- IPC: C07D239/12 ; C07D401/04 ; C07D401/10 ; C07D239/30

Abstract:
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
Public/Granted literature
- US20140142119A1 INHIBITORS OF INFLUENZA VIRUSES REPLICATION Public/Granted day:2014-05-22
Information query